How I treat the young patient with multiple myeloma
نویسندگان
چکیده
منابع مشابه
How I Treat How I treat smoldering multiple myeloma
Although the last decade has seen the development of effective targeted therapies for patients with multiple myeloma (MM), the clinical utility of targeted therapies has been hampered by the development of drug resistance, clonal evolution, and disease progression, making the quest for cure ever more elusive for MM. However, one may argue that the concept of initiating therapy at the time of sy...
متن کاملHow I treat smoldering multiple myeloma.
Smoldering myeloma is a heterogeneous clinical entity where a subset of patients has an indolent course of disease that mimics monoclonal gammopathy of undermined significance, whereas others have a more aggressive course that has been described as "early myeloma." It is defined as either serum M-protein ≥ 3 g/L or ≥ 10% monoclonal plasma cells in the bone marrow. There are currently no molecul...
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The clinical approach to older patients with myeloma has to be modified to take into account comorbidities and the likelihood of higher treatment-related toxicity. Individualization of management and adequate supportive therapy are important to obtain the best response while minimizing adverse effects. Corticosteroids, novel agents, conventional cytotoxic agents, and high-dose chemotherapy with...
متن کاملHow to treat a newly diagnosed young patient with multiple myeloma.
Survival rates of young patients with myeloma have increased markedly in the last decade, mainly due to the use of autologous stem cell transplantation (ASCT) and new, highly efficient rescue treatments. In order to improve the survival of newly diagnosed young patients further, the next steps need to focus on increasing the activity of upfront or debulking regimens, improving the efficacy of A...
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The incorporation of the novel drugs thalidomide, bortezomib, and lenalidomide has resulted in a significant survival prolongation in patients with multiple myeloma (MM). However, MM remains incurablewith an important life-expectancy shortening.Autologous stem cell transplantation (ASCT) is the gold standard in younger patients and the incorporation of novel drugs in the induction phase has imp...
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ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2017-05-693606